PGut GI + Immune Support

• Patented probiotics can alleviates GI discomfort & relieves bloating associated with irritable bowel
  syndrome (IBS), inflammatory bowel disease (IBD) and colitis. Also irt may suppress the growth of
  harmful bacteria and restore benign bacteria in the gut after antibiotic treatments, diarrhea,
  constipation and GI infection.
• Lactobacillus plantarum – promotes gut health by diversifying colon microbiota and increasing the
  Firmicutes to Bacteroidetes (F/B) ratio1 as a ubiquitous indicator of a healthy gut since it restricts
  pathogenic bacterial activities.
• Lactococcus lactis – inhibits the motility of pathogenic bacteria such as Salmonella, Pseudomonas,
  Vibrio and Leptospira by generating acetate through lactose metabolism.
• Bifidobacterium breve – stimulates the activity of mitochondrial dehydrogenases of macrophages and the
  production of IL-6 for activating immune responses. It also reduces the number of gut pathogenic
  bacteria, such as Campylobacter, Candida and Enterococcus spp. and hence stabilizes the intestinal
  microbial composition.

Bifidobacterium lactis – effectively increases the content of IFN-γ and IgG2a, which are produced by
Th1 cells and inhibit the secretion of IL-4、IL5、IL13 from Th2 cells. Consequently, IgE produced by B
cells are suppressed and results in reduction of allergic reactions.

Lactobacillus paracasei – produces lactocepin to selectively degrade pro-inflammatory chemokines,
resulting in reduced immune cell infiltration and inflammation.8 This probiotic can also stimulate the
immune system by the induction of proinflammatory cytokines, such as interleukin-12 (IL-12).

Symbiotic formulation: Oligosaccharide prebiotics (GOS, FOS and inulin) provide
comprehensive support to gastrointestinal microflora growth and promote bacterial
metobolism.

Symbiotic bacteria: Streptococcus thermophilus GKT2 strengthens colonizing ability of
probiotics by producing metabolites such as folic acid and fatty acids to promote
Lactobacillus growth.